| Organism | Number of inteins | Intein name | Protein host | EN domain type1 | Integration point (number of known alleles) |
|---|---|---|---|---|---|
| Eucarya | |||||
| Saccharomyces cerevisiae | 1 | Sce VMA | Vacuolar ATPase catalytic subunit | DOD | VMA-a (16) |
| | |||||
| Saccharomyces castellii CBS-4309 | 1 or more | Sca VMA | Vacuolar ATPase catalytic subunit | DOD | VMA-a (16) |
| | |||||
| Saccharomyces species DH1-1A | 1 or more | SceDH1-1A VMA1 | Vacuolar ATPase catalytic subunit | DOD | VMA-a (16) |
| | |||||
| Saccharomyces cariocanus UFRJ-50791 | 1 or more | Scar VMA | Vacuolar ATPase catalytic subunit | DOD | VMA-a (16) |
| | |||||
| Saccharomyces dairenensis CBS-421 | 1 or more | Sda VMA | Vacuolar ATPase catalytic subunit | DOD | VMA-a (16) |
| | |||||
| Saccharomyces exiguus CBS-379 | 1 or more | Sex VMA | Vacuolar ATPase catalytic subunit | DOD | VMA-a (16) |
| | |||||
| Saccharomyces unisporous CBS-398 | 1 or more | Sun VMA | Vacuolar ATPase catalytic subunit | DOD | VMA-a (16) |
| | |||||
| Kluyveromyces lactis CBS-683 | 1 or more | Kla VMA | Vacuolar ATPase catalytic subunit | DOD | VMA-a (16) |
| | |||||
| Kluyveromyces polysporus CBS-2163 | 1 or more | Kpo VMA | Vacuolar ATPase catalytic subunit | DOD | VMA-a (16) |
| | |||||
| Zygosaccharomyces bailii CBS-685 | 1 or more | Zba VMA | Vacuolar ATPase catalytic subunit | DOD | VMA-a (16) |
| | |||||
| Zygosaccharomyces bisporus CBS-702 | 1 or more | Zbi VMA | Vacuolar ATPase catalytic subunit | DOD | VMA-a (16) |
| | |||||
| Zygosaccharomyces rouxii CBS-688 | 1 or more | Zro VMA | Vacuolar ATPase catalytic subunit | DOD | VMA-a (16) |
| | |||||
| Torulaspora globosa CBS-764 | 1 or more | Tgl VMA | Vacuolar ATPase catalytic subunit | DOD | VMA-a (16) |
| | |||||
| Torulaspora pretoriensis CBS-5080 | 1 or more | Tpr VMA | Vacuolar ATPase catalytic subunit | DOD | VMA-a (16) |
|
|
|||||
| Candida glabrata | 1 or more | Cgl VMA | Vacuolar ATPase catalytic subunit | DOD | VMA-a (16) |
| | |||||
| Candida tropicalis | 1 or more | Ctr VMA | Vacuolar ATPase catalytic subunit | DOD | VMA-a (16) |
| | |||||
| Filobasidiella (Cryptococcus) neoformans | 1 or more | Cne PRP8 | pre-mRNA splicing factor Prp8 | - | PRP8-a (4) |
| | |||||
| Ajellomyces (Histoplasma) capsulatus | 1 or more | Hca PRP8 | pre-mRNA splicing factor Prp8 | DOD | PRP8-a (4) |
| | |||||
| Aspergillus fumigatus | 1 or more | Afu PRP8 | pre-mRNA splicing factor Prp8 | DOD | PRP8-a (4) |
| | |||||
| Emericella (Aspergillus) nidulans FGSC-4A | 1 or more | Ani PRP8 | pre-mRNA splicing factor Prp8 | DOD | PRP8-a (4) |
| |
|||||
| Chlamydomonas eugametos chloroplast | 1 or more | Ceu clpP | Clp protease catalytic subunit | DOD | clpP-a (1) |
| | |||||
| Porphyra purpurea chloroplast | 1 | Ppu dnaB | DnaB helicase | - | dnaB-a (9) |
| | |||||
| Guillardia theta plastid | 1 | Gth dnaB | DnaB helicase | - | dnaB-a (9) |
| | |||||
| Chilo iridescent virus (CIV) | 1 or more | CIV RIR1 | class-I Ribonucleotide reductase a subunit | DOD | RIR1-b (20) |
| Bacteria | |||||
| Mycobacterium tuberculosis | 3 | Mtu recA | RecA | DOD | recA-a (1) |
| Mtu pps1 | Uncharacterized protein, Interpro family UPF0051 (E.coli sufD homologs, mycobacterial pps1 proteins) | DOD | pps1-b (4) | ||
| Mtu dnaB | DnaB helicase | DOD | dnaB-a (9) | ||
| | |||||
| Mycobacterium leprae | 4 | Mle recA | RecA | DOD | recA-b (9) |
| Mle pps1 | Uncharacterized protein, Interpro family UPF0051 (E.coli sufD homologs, mycobacterial pps1 proteins) | DOD | pps1-a (1) | ||
| Mle gyrA | DNA gyrase subunit A | DOD | gyrA-a (7) | ||
| Mle dnaB | DnaB helicase | - | dnaB-b (8) | ||
| | |||||
| Mycobacterium smegmatis | 2 or more | Msm dnaB-1 | DnaB helicase | - | dnaB-b (8) |
| Msm dnaB-2 | DOD | dnaB-a (9) | |||
| | |||||
| Mycobacterium avium paratuberculosis | 1 or more | MavPT dnaB | DnaB helicase | DOD | dnaB-b (8) |
| | |||||
| Mycobacterium avium | 1 or more | Mav dnaB | DnaB helicase | DOD | dnaB-b (8) |
| | |||||
| Mycobacterium intracellulare | 1 or more | Min dnaB | DnaB helicase | DOD | dnaB-b (8) |
| | |||||
| Mycobacterium flavescens | 2 or more | Mfl gyrA | DNA gyrase subunit A | DOD | gyrA-a (7) |
| Mfl recA | RecA | DOD | recA-b (9) | ||
| | |||||
| Mycobacterium gordonae | 1 or more | Mgo gyrA | DNA gyrase subunit A | DOD | gyrA-a (7) |
| | |||||
| Mycobacterium kansasii | 1 or more | Mka gyrA | DNA gyrase subunit A | DOD | gyrA-a (7) |
| | |||||
| Mycobacterium malmoense | 1 or more | Mma gyrA | DNA gyrase subunit A | DOD | gyrA-a (7) |
| | |||||
| Mycobacterium xenopi | 1 or more | Mxe gyrA | DNA gyrase subunit A | - | gyrA-a (7) |
| | |||||
| Mycobacterium fallax | 1 or more | Mfa recA | RecA | DOD | recA-b (9) |
| | |||||
| Mycobacterium chitae | 1 or more | Mch recA | RecA | DOD | recA-b (9) |
| | |||||
| Mycobacterium flavescens ATCC14474 | 1 or more | Mfl recA 14474 | RecA | DOD | recA-b (9) |
| | |||||
| Mycobacterium gastri | 3 or more | Mga recA | RecA | DOD | recA-b (9) |
| Mga gyrA | DNA gyrase subunit A | DOD | gyrA-a (7) | ||
| Mga pps1 | Uncharacterized protein, Interpro family UPF0051 (E.coli sufD homologs, mycobacterial pps1 proteins) | DOD | pps1-c (1) | ||
| | |||||
| Mycobacterium shimoidei | 1 or more | Msh recA | RecA | DOD | recA-b (9) |
| | |||||
| Mycobacterium thermoresistibile | 1 or more | Mth recA | RecA | DOD | recA-b (9) |
| | |||||
| Synechocystis spp. PCC6803 | 4 2 | Ssp dnaB | DnaB helicase | DOD | dnaB-a (9) |
| Ssp dnaX | DNA polymerase III t subunit (dnaX gene) | unknown | dnaX-a (2) | ||
| Ssp gyrB | DNA gyrase subunit B | HNH | gyrB-a (2) | ||
| Ssp DnaE 2 | DNA polymerase III a subunit | - | dnaE-a (13) | ||
| | |||||
| Synechococcus spp. PCC7002 | 3 2 | Ssp2 Thy1 | Conserved protein similar to halobacterial Thy1 thymidylate synthase complementing protein | HNH | Thy1-a (2) |
| Ssp2 RfbB | dTDP-glucose 4-6-dehydratase | DOD | rfbB-a (2) | ||
| Ssp2 DnaE 2 | DNA polymerase III a subunit | - | dnaE-a (13) | ||
| | |||||
| Nostoc spp. PCC7120 (Anabaena PCC7120) | 3 2 | Asp dnaB | DnaB helicase | DOD | dnaB-a (9) |
| Asp RIR1 | class-I Ribonucleotide reductase a subunit | DOD | RIR1-d (2) | ||
| Asp DnaE 2 | DNA polymerase III a subunit | - | dnaE-a (13) | ||
| | |||||
| Nostoc punctiforme (ATCC29133, PCC73102) | 3 or more 2 | Npu dnaB | DnaB helicase | DOD | dnaB-a (9) |
| Npu rtcB | Uncharacterized protein, Interpro family UPF0027 (E.coli rtcB homologs) | HNH | rtcB-a (6) | ||
| Npu DnaE 2 | DNA polymerase III a subunit | - | dnaE-a (13) | ||
| | |||||
| Trichodesmium erythraeum IMS101 | 142 | Ter dnaB-1 | DnaB helicase | DOD | dnaB-b (8) |
| Ter dnaB-2 | - | dnaB-a (9) | |||
| Ter gyrB | DNA gyrase subunit B | - | gyrB-a (2) | ||
| Ter Thy1 | Conserved protein similar to halobacterial Thy1 thymidylate synthase complementing protein | - | Thy1-a (2) | ||
| Ter RfbB-1 | dTDP-glucose 4-6-dehydratase | DOD | rfbB-a (2) | ||
| Ter RfbB-2 | DOD | rfbB-b (1) | |||
| Ter snf2 | SNF2 helicase | DOD | snf2-a (2) | ||
| Ter RIR1-1 | class-II Ribonucleotide reductase | - | RIR1-d (2) | ||
| Ter RIR1-2 | DOD | RIR1-b (20) | |||
| Ter RIR1-3 | DOD | RIR1-f (1) | |||
| Ter RIR1-4 | DOD | RIR1-g (1) | |||
| Ter DnaE1-1 | DNA polymerase III a subunit | DOD | dnaE-d (1) | ||
| Ter DnaE1-2 | DOD | dnaE-b (2) | |||
| Ter DnaE-3 2 | - | dnaE-a (13) | |||
| | |||||
| Crocosphaera watsonii WH8501 | 4 or more 2 | Cwa dnaB | DnaB helicase | DOD | dnaB-b (8) |
| Cwa PEPsyn | Phosphoenol pyruvate synthase | DOD | PEPsyn-a (2) | ||
| Cwa RIR1 | class-I Ribonucleotide reductase a subunit | DOD | RIR1-b (20) | ||
| Cwa DnaE 2 | DNA polymerase III a subunit | - | dnaE-a (13) | ||
| | |||||
| Synechococcus elongatus PCC7942 | 2 2 | Sel RIR1 | class-I Ribonucleotide reductase a subunit | DOD | RIR1-b (20) |
| Sel DnaE 2 | DNA polymerase III a subunit | - | dnaE-a (13) | ||
| | |||||
| Gloeobacter violaceus PCC7421 | 3 | Gvi RIR1-1 | class-I Ribonucleotide reductase a subunit | DOD | RIR1-e (2) |
| Gvi RIR1-2 | DOD | RIR1-b (20) | |||
| Gvi dnaB | DnaB helicase | DOD | dnaB-b (8) | ||
| | |||||
| Spirulina platensis C1 | 1 or more | Spl dnaX | DNA polymerase III t subunit (dnaX gene) | - | dnaX-a (2) |
| | |||||
| Aphanizomenon ovalisporum | 1 or more 2 | Aov DnaE 2 | DNA polymerase III a subunit | - | dnaE-a (13) |
| | |||||
| Oscillatoria limnetica | 1 or more 2 | Oli DnaE 2 | DNA polymerase III a subunit | - | dnaE-a (13) |
| | |||||
| Thermosynechococcus elongatus BP-1 | 1 2 | Tel DnaE 2 | DNA polymerase III a subunit | - | dnaE-a (13) |
| | |||||
| Thermosynechococcus vulcanus | 1 or more 2 | Tvu DnaE 2 | DNA polymerase III a subunit | - | dnaE-a (13) |
| | |||||
| Anabaena variabilis ATCC29413 | 1 or more 2 | Ava DnaE 2 | DNA polymerase III a subunit | - | dnaE-a (13) |
| | |||||
| Aphanothece halophytica | 1 or more 2 | Aha DnaE 2 | DNA polymerase III a subunit | - | dnaE-a (13) |
| | |||||
| Rhodothermus marinus | 1 or more | Rma dnaB | DnaB helicase | DOD | dnaB-a (9) |
| | |||||
| Thermomonospora fusca | 2 or more | Tfus recA-1 | RecA | DOD | recA-c (2) |
| Tfus recA-2 | DOD | recA-b (9) | |||
| | |||||
| Aquifex aeolicus | 1 | Aae RIR2 | class-I Ribonucleotide reductase b subunit | DOD | RIR2-a (1) |
| | |||||
| Deinococcus radiodurans | 2 | Dra RIR1 | class-II Ribonucleotide reductase | DOD | RIR1-b (20) |
| Dra snf2 | SNF2 helicase | DOD | snf2-a (2) | ||
| | |||||
| Thermus thermophilus | 4 or more | Tth RIR1-1 | class-II Ribonucleotide reductase | DOD | RIR1-e (2) |
| Tth RIR1-2 | DOD | RIR1-b (20) | |||
| Tth DnaE-1 | DNA polymerase III a subunit | DOD | dnaE-b (2) | ||
| Tth DnaE-2 | DOD | dnaE-c (2) | |||
| | |||||
| Chloroflexus aurantiacus | 1 or more | Cau SpoVR | SpoVR - function unknown, family includes B.subtilis protein involved in spore cortex synthesis, related proteins from other bacilli, enterobacteria (E.coli YcgB), Pseudomonads and an Archaeon (Halobacterium) | - | SpoVR-a (1) |
| | |||||
| Methylobacterium extorquens | 2 or more | Mex trbC | TrbC - a protein with an AAA ATPase domain (see Interpro domain AAA ATPases) | DOD | trbC-a (1) |
| Mex Helic | Some type of helicase (see Interpro families Helicases and DEAD/DEAH box helicases) | - | 00302-a (1) | ||
| | |||||
| Methylococcus capsulatus | 2 or more | Mca RIR3 | class-II Ribonucleotide reductase | DOD | RIR1-b (20) |
| Mca MupF | phage Mu protein F homolog - function unknown | unknown | MupF-a (1) | ||
| | |||||
| Azotobacter vinelandii | 1 or more | Avi RIR1 | class-I Ribonucleotide reductase a subunit | DOD | RIR1-f (1) |
| | |||||
| Coxiella burnetii | 1 or more | Cbu dnaB | DnaB helicase | - | dnaB-c (1) |
| | |||||
| Carboxydothermus hydrogenoformans | 1 or more | Chy RIR1 | class-I Ribonucleotide reductase a subunit | DOD | RIR1-b (20) |
| | |||||
| Desulfitobacterium hafniense | 1 or more | Dha RIR1 | class-I Ribonucleotide reductase a subunit | DOD | RIR1-b (20) |
| | |||||
| Staphylococcus epidermidis | 1 or more | Sep RIR1 | class-I Ribonucleotide reductase a subunit | DOD | RIR1-b (20) |
| | |||||
| Gemmata obscuriglobus UQM 2246 | 2 or more | Gob o681 | Bacterial conserved hypothetical protein of unknown function; has N' ParB nuclease domain and C' DNA methylase domain (see Interpro domains ParB nuclease and DNA methylase) | unknown | o681-a (1) |
| Gob DnaE | DNA polymerase III a subunit | DOD | dnaE-c (2) | ||
| | |||||
| SPb phage (integrated as a prophage in the Bacillus subtilis genome) |
1 | Spb RIR1 | class-I Ribonucleotide reductase a subunit | DOD | RIR1-b (20) |
| | |||||
| A phage of Bacillus spp. M1918 (integrated as a prophage in the Bacillus species M1918 genome) |
1 or more | BspM1918 RIR1 | class-I Ribonucleotide reductase a subunit | DOD | RIR1-b (20) |
| | |||||
| Clostridium thermocellum (probably a prophage) | 1 | Cth terA | Protein similar to a type of phage terminase large subunits (E.coli ymfN gene) | DOD | terA-a (1) |
| | |||||
| Bacteriophage APSE-1 (infecting the secondary endosymbiont of Acyrthosiphon pisum) | 1 | APSE1 dpo1 | DNA polymerase I | - | dpo1-a (1) |
| Archaea | |||||
| Thermoplasma acidophilum | 1 | Tac VMA | Vacuolar-type ATPase catalytic subunit | - | VMA-b (7) |
| | |||||
| Thermoplasma volcanium | 1 | Tvo VMA | Vacuolar-type ATPase catalytic subunit | - | VMA-b (7) |
| | |||||
| Ferroplasma acidiphilum | 2 or more | Fac RIR1 | class-II Ribonucleotide reductase | DOD | RIR1-b (20) |
| Fac pps1 | Uncharacterized protein, Interpro family UPF0051 (E.coli sufD homologs, mycobacterial pps1 proteins) | DOD | pps1-b (4) | ||
| | |||||
| Ferroplasma acidarmanus type I | 2 or more | FacI RIR1 | Ribonucleotide reductase | DOD | RIR1-b (20) |
| FacI pps1 | Uncharacterized protein, Interpro family UPF0051 (E.coli sufD homologs, mycobacterial pps1 proteins) | DOD | pps1-b (4) | ||
| | |||||
| Ferroplasmaspecies type II | 3 or more | FspII RIR1 | Ribonucleotide reductase | DOD | RIR1-b (20) |
| FspII pps1 | Uncharacterized protein, Interpro family UPF0051 (E.coli sufD homologs, mycobacterial pps1 proteins) | DOD | pps1-b (4) | ||
| FspII VMA | Vacuolar-type ATPase catalytic subunit | DOD | VMA-b (7) | ||
| | |||||
| Picrophilus torridusDSM 9790 | 1 | Pto VMA | Vacuolar-type ATPase catalytic subunit | DOD | VMA-b (7) |
| | |||||
| Halobacterium spp. NRC-1 | 2 | Hsp polC | Archaeal DNA polymerase Pol II, DP2 subunit (Archaeal polC gene) | - | polC-a (4) |
| Hsp CDC21 | Cell division control protein 21 (CDC21) | - | CDC21-a (4) | ||
| | |||||
| Haloferax volcanii DS2 ATCC29605 | 1 | Hvo PolB1 | DNA polymerase family B (archaeal polA gene) | DOD | pol-c3 (7) |
| | |||||
| Haloarcula marismortui ATCC43049 | 4 | Hma polC | Archaeal DNA polymerase Pol II, DP2 subunit (Archaeal polC gene) | - | polC-a (4) |
| Hma CDC21 | Cell division control protein 21 (CDC21) | DOD | CDC21-a (4) | ||
| Hma PolB1 | DNA polymerase family B (archaeal polA gene) | DOD | pol-b3 (9) | ||
| Hma TopA | DNA topoisomerase I | DOD | topA-a (1) | ||
| | |||||
| Methanobacterium thermoautotrophicum | 1 | Mth RIR1 | class-II Ribonucleotide reductase | - | RIR1-b (20) |
| | |||||
| Methanococcoides burtonii | 1 or more | Mbu terA2 | Similar to a type of phage terminase large subunits (i.e. Rhodobacter capsulatusputative terminase large subunit) | - | terA2-a (1) |
| | |||||
| Methanopyrus kandleri AV19 | 5 | Mka CDC48 | CDC48 ATPase cell division control protein 48 | DOD | CDC48-a (1) |
| Mka rtcB | Uncharacterized protein, Interpro family UPF0027 (E.coli rtcB homologs) | DOD | rtcB-a (6) | ||
| Mka VatB | Vacuolar-type ATPase b subunit | DOD | VatB-a (1) | ||
| Mka EF2 | EF2 translation elongation and release factor fusA | DOD | IF2-a (5) | ||
| Mka RFC | Replication factor C, 37 Kd subunit | - | RFC-b (2) | ||
| | |||||
| Thermococcus spp. GE8 | 2 or more | TspGE8 pol-1 | DNA polymerase family B (archaeal polA gene) | DOD | pol-b3 (9) |
| TspGE8 pol-2 | DOD | pol-c3 (7) | |||
| | |||||
| Thermococcus hydrothermalis | 2 or more | Thy pol-1 | DNA polymerase family B (archaeal polA gene) | DOD | pol-b3 (9) |
| Thy pol-2 | DOD | pol-c3 (7) | |||
| | |||||
| Thermococcus litoralis | 2 or more | Tli pol-1 | DNA polymerase family B (archaeal polA gene) | DOD | pol-b3 (9) |
| Tli pol-2 | DOD | pol-c3 (7) | |||
| | |||||
| Thermococcus fumicolans | 2 or more | Tfu pol-1 | DNA polymerase family B (archaeal polA gene) | DOD | pol-a3 (4) |
| Tfu pol-2 | DOD | pol-c3 (7) | |||
| | |||||
| Thermococcus aggregans | 3 or more | Tag pol-1 | DNA polymerase family B (archaeal polA gene) | DOD | pol-a3 (4) |
| Tag pol-2 | DOD | pol-b3 (9) | |||
| Tag pol-3 | - | pol-c3 (7) | |||
| | |||||
| Pyrococcus spp. GB-D | 1 or more | Psp pol-1 | DNA polymerase family B (archaeal polA gene) | DOD | pol-b3 (9) |
| | |||||
| Pyrococcus kodakaraensis (strain KOD1) | 2 or more | Pko pol-1 | DNA polymerase family B (archaeal polA gene) | DOD | pol-a3 (4) |
| Pko pol-2 | DOD | pol-b3 (9) | |||
| | |||||
| Pyrococcus furiosus | 10 | Pfu RIR1-1 | class-II Ribonucleotide reductase | DOD | RIR1-a (2) |
| Pfu RIR1-2 | DOD | RIR1-b (20) | |||
| Pfu topA | DNA topoisomerase I | DOD | r-gyr-a (3) | ||
| Pfu rtcB4 | Uncharacterized protein, Interpro family UPF0027 (E.coli rtcB homologs) | DOD | rtcB-a (6) | ||
| Pfu IF2 | Translation initiation factor bIF-2 | DOD | IF2-a (5) | ||
| Pfu CDC21 | Cell division control protein 21 (CDC21) | DOD | CDC21-b (3) | ||
| Pfu RFC | Replication factor C, 37 Kd subunit | DOD | RFC-a (4) | ||
| Pfu lon | ATP-dependent protease LA (lon gene) | DOD | lon-a (3) | ||
| Pfu VMA | Vacuolar-type ATPase catalytic subunit | DOD | VMA-b (7) | ||
| Pfu klbA | KlbA virulence protein | DOD | klbA-a (4) | ||
| | |||||
| Pyrococcus horikoshii OT3 | 14 | Pho pol | DNA polymerase family B (archaeal polA gene) | DOD | pol-b3 (9) |
| Pho polC | Archaeal DNA polymerase Pol II, DP2 subunit (Archaeal polC gene) | - | polC-a (4) | ||
| Pho rtcB4 (PH1602) | Uncharacterized protein, Interpro family UPF0027 (E.coli rtcB homologs) | DOD | rtcB-a (6) | ||
| Pho LHR | ATP dependent helicase; LHR - large helicase-related protein |
DOD | LHR-a (1) | ||
| Pho IF2 | Translation initiation factor bIF-2 | DOD | IF2-a (5) | ||
| Pho RIR1 | class-II Ribonucleotide reductase | DOD | RIR1-b (20) | ||
| Pho CDC21-1 | Cell division control protein 21 (CDC21) | - | CDC21-a (4) | ||
| Pho CDC21-2 | - | CDC21-b (3) | |||
| Pho RFC | Replication factor C, 37 Kd subunit | DOD | RFC-a (4) | ||
| Pho r-gyr | DNA reverse gyrase | DOD | r-gyr-a (3) | ||
| Pho lon | ATP-dependent protease LA (lon gene) | DOD | lon-a (3) | ||
| Pho VMA | Vacuolar-type ATPase catalytic subunit | DOD | VMA-b (7) | ||
| Pho radA | DNA repair protein radA (RAD51, recA homolog) | - | recA-c (2) | ||
| Pho klbA | KlbA virulence protein | DOD | klbA-a (4) | ||
| | |||||
| Pyrococcus abyssi | 14 | Pab polC | Archaeal DNA polymerase Pol II, DP2 subunit (Archaeal polC gene) | - | polC-a (4) |
| Pab rtcB4 (PAB0383) | Uncharacterized protein, Interpro family UPF0027 (E.coli rtcB homologs) | DOD | rtcB-a (6) | ||
| Pab IF2 | Translation initiation factor bIF-2 | DOD | IF2-a (5) | ||
| Pab RIR1-1 | class-II Ribonucleotide reductase | DOD | RIR1-a (2) | ||
| Pab RIR1-2 | DOD | RIR1-c (1) | |||
| Pab RIR1-3 | DOD | RIR1-b (20) | |||
| Pab CDC21-1 | Cell division control protein 21 (CDC21) | - | CDC21-a (4) | ||
| Pab CDC21-2 | - | CDC21-b (3) | |||
| Pab RFC-1 | Replication factor C, 37 Kd subunit | DOD | RFC-a (4) | ||
| Pab RFC-2 | DOD | RFC-c (2) | |||
| Pab lon | ATP-dependent protease LA (lon gene) | DOD | lon-a (3) | ||
| Pab VMA | Vacuolar-type ATPase catalytic subunit | DOD | VMA-b (7) | ||
| Pab klbA | KlbA virulence protein | - | klbA-a (4) | ||
| Pab moaA | Molybdenum cofactor biosynthesis A (MoaA) like protein | DOD | moaA-a (1) | ||
| | |||||
| Methanococcus jannaschii | 19 | Mja pol-1 | DNA polymerase family B (archaeal polA gene) | DOD | pol-a3 (4) |
| Mja pol-2 | DOD | pol-b3 (9) | |||
| Mja hyp1 (MJ0043) | Archaeal uncharacterized protein (M.jannaschii MJ0043) | DOD | hyp1-a (1) | ||
| Mja rtcB4 (MJ0682) | Uncharacterized protein, Interpro family UPF0027 (E.coli rtcB homologs) | DOD | rtcB-a (6) | ||
| Mja helicase (MJ1124) | DEAD/DEAH-box helicase | DOD | helica.-a (1) | ||
| Mja GF6P | Glutamine fructose 6 phosphate transaminase | DOD | GF6P-a (1) | ||
| Mja IF2 | Translation initiation factor bIF-2 | DOD | IF2-a (5) | ||
| Mja RNR-1 | class-III (anaerobic) Ribonucleotide reductase | DOD | RNR-a (1) | ||
| Mja RNR-2 | DOD | RNR-b (1) | |||
| Mja PEPsyn | Phosphoenol pyruvate synthase | DOD | PEPsyn-a (2) | ||
| Mja RFC-1 | Replication factor C, 37 Kd subunit | DOD | RFC-a (4) | ||
| Mja RFC-2 | DOD | RFC-b (2) | |||
| Mja RFC-3 | DOD | RFC-c (2) | |||
| Mja RpolA' | RNA polymerase subunit A' | DOD | RpolA'-a (1) | ||
| Mja RpolA" | RNA polymerase subunit A" | DOD | RpolA"-a (1) | ||
| Mja TFIIB | Transcription factor IIB | DOD | TFIIB-a (1) | ||
| Mja r-gyr | DNA reverse gyrase | DOD | r-gyr-a (3) | ||
| Mja UDPGD | UDP-glucose dehydrogenase | DOD | UDPGD-a (1) | ||
| Mja klbA | KlbA virulence protein | - | klbA-a (4) | ||
| | |||||
| Aeropyrum pernix | 1 | Ape hyp3 (APE0745) | Archaeal uncharacterized protein (A.pernix APE0745) | DOD | hyp3-a (1) |
| | |||||
| Nanoarchaeum equitans Kin4-M | 1 | Neq pol 2 | DNA polymerase family B (archaeal polA gene) | - | pol-c 3 (7) |
| Totals: | |||||
| 99 different species and strains. 24 eukaryotes (20 in unicellular organisms, 3 in plastids and 1 in viruses), 50 bacteria (4 in bacterio- and pro- phages), 25 archaea. |
216 inteins 2 | 46 types of protein family hosts 5.
187 separate proteins with inteins: 150 with a single intein, 14 pairs each with one split intein 2, 18 with 2 inteins, 3 with 3 inteins, 1 with 4 inteins, and 1 pair: one with two and half inteins and the other with half of an intein (the two halves being parts of a split intein) |
2 known EN domain types1, 47 inteins without an EN domain | 71 different integration points, 36 with more than one allele | |
1 Known intein endonuclease (EN) domain types: DOD - dodecapeptide
(LAGLI-DADG) and HNH (see Belfort
and Roberts '97).
2 Cyanobacterial DnaEs and Nanoarchaeum equitans
pol are split inteins - the N' and C' parts of the inteins are
found on different protein molecules (e.g., the N' and C' parts of the DNA polymerase
III a subunit [DnaE or PolC], respectively, and
the pol1 and pol2 N' and C' parts of the Neq DNA polymerase type B). These
two molecules are probably trans protein-spliced to form the mature DnaE
or PolA proteins.
3The intein integration points in the type B DNA polymerases
have been renamed on April '99. I joined the NEB Intein database and renamed
the integration points according the type B DNA polymerase domain in which
they are present. See positions of inteins
in their host proteins. Integration point pol-a was used to be called
here pol-c, pol-b was used to be called pol-a and pol-c was used to be
called pol-b. The colors of the integartion points are unchanged.
4 Interpro family UPF0027 (E.coli
rtcB homologs) was previously named here "hyp2". The function of these
proteins is still unknown but now they are named and better characterized.
Details can be found in
Genschik, Drabikowski & Filipowicz, J Biol Chem 273:25516-25526 (1998).
5 In counting the types of protein families with inteins
DNA reverse gyrases are grouped together with Topoisomerase type I, Replication
factor C, 37 Kd subunits are grouped together with DNA pol-3 t subunits, and translation initiation factor bIF-2
are grouped together with EF2 translation elongation and release factors.