Comparison between M.jannaschii and Pyrococcus horikoshii OT3 inteins (May 98')

Protein host Methanococcus jannaschii
homolog
Mja intein Pyrococcus horikoshii OT3
homolog
Pho intein Same integration point ?

Intein in both species
Translation initiation factor bIF-2 MJ0262 Mja IF2 PH1095 Pho IF2 Y
KlbA virulence protein MJ0781 Mja klbA PH0650 Pho klbA Y
DNA reverse gyrase MJ1512 Mja r-gyr PH0800 Pho r-gyr Y
Unknown function MJ0682 Mja rtcB PH1602 Pho rtcB Y
Replication factor C, 37 Kd subunit MJ1422 Mja RFC-1/2/3 PH0112 Pho RFC Y (with Mja 1)
DNA polymerase family B (archaeal polA gene) MJ0885 Mja pol-1/2 PH1947 Pho pol Y (with Mja 2)

Intein only in Pho
Vacuolar-type ATPase catalytic subunit MJ0217 - PH1975 Pho VMA -
DNA repair protein radA (RAD51, recA homolog) MJ0869 - PH0263 Pho radA -
ATP-dependent protease LA (lon gene) MJ1417 - PH0452 Pho lon -
Subunit 2 of an archaeal DNA polymerase (archaeal polC gene) MJ1630 - PH0121 Pho polC -
Cell division control protein 21 (CDC21) MJ1489 / MJ0961 / MJ0363 - PH0606 Pho CDC21-1/2 -
class-II Ribonucleotide reductase no Mja homolog - PH0363 Pho RIR1 -
An ATP dependent helicase
LHR - large helicase-related protein
MJ0294 - PH1110 Pho LHR 1

Intein only in Mja
A helicase MJ1124 Mja helica. PH1280 - 1
Phosphoenol pyruvate synthase MJ0542 Mja PEPSyn PH0092 - -
Transcription factor IIB MJ0782 Mja TFIIB PH1482 - -
UDP-glucose dehydrogenase MJ1054 Mja UDPGD PH1618 - -
Unknown function MJ0043 Mja hyp1 PH1535 - -
Glutamine fructose 6 phosphate transaminase MJ1420 Mja GF6P PH0243 - -
class-III (anaerobic) Ribonucleotide reductase MJ0832 Mja RNR-1/2 PH0021 - -
RNA polymerase subunit A' MJ1043 Mja RpolA' PH1544 - -
RNA polymerase subunit A" MJ1042 Mja RpolA" PH1545 - -

1 The closest Mja homologs of PH1110 (LHR) and PH1280, and their probable functional equivalents, are MJ0294 and MJ1124, respectively. However, Both pairs of proteins are helicases with distant, but clear, common ancestor (homologs). The intein integration sites in MJ1124 and PH1110 are not the same.


More information on M.jannaschii (TIGR) and Pyrococcus horikoshii OT3 (NITE Biotechnology Center).
See a comparison between intein distribution in fully sequenced Archaea, additional information on all inteins listed by species and by host proteins and a list of inteins in the Pyrococcus horikoshii OT3 genome.


[Inteins home page]
Page last modified May 1998
Shmuel Pietrokovski <pietro@weizmann.ac.il>